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TweetDeck and Seesmic are desktop clients designed to make communicating on Twitter and managing your accounts easier.
Here they go, head to head: TweetDeck version 0.26 versus Seesmic version 0.4.
Look & Feel
Both TweetDeck and Seesmic are built using the Adobe AIR platform, and have a similar look and feel.
Seemsic appears to have more subtleties designed to make it easier to decipher tweets from multiple accounts at once, yet neither application is hugely customisable when it comes to the overall look.
If you only run a single Twitter account then seeing how applications handle multiple accounts won’t matter to you, but if you’re a “power user” handling two or more active accounts, you’ll find Seesmic offers more options for handling them.
Both applications let you view columns for each account’s tweets, replies, direct messages and so on, but Seesmic also allows you to view a single stream of messages from all your accounts at once, ordered by the time tweets arrive.
Whether this works for you depends on how you like to view accounts, but at least you have the option. TweetDeck (currently) doesn’t offer this.