Mice without Cdk5 brain enzyme are smarter



UT Southwestern scientists built a better mouse brain by knocking out the Cdk5 brain enzyme. “Everything is more meaningful to these mice,” said the study’s senior author, Dr. James Bibb. “The increase in sensitivity to their surroundings seems to have made them smarter.” A new technique called “conditional knock out” allowed the team to actually remove the enzyme in adult mice, where previous methods required eliminating the entire gene. Developing. [GT]

Losing brain enzyme makes mice ‘smarter’

Gabrielle Taylor