Some rather cool iPad software (and device) from Griffin that turns your tablet into a remote contol. The interface looks very easy and it seems simple to add devices. It can cope with Macros (one flick turns the TV on and the sat receiver too) also pulls in a TV guide too.
It works on touchs and iPhones too and the Android version is imminent.
The app will be out in Spring and costs around $80 US. Not sure about UK pricing yet.